Ossylbone™ is a fully biocompatible, biodegradable and safe material that mimics the natural bone structure and by that its able to effectively support the regeneration of the bone tissue. Ossylbone™ biomimetic bone substitute is composed of hydroxyapatite (HAp) (75%) and tricalcium phosphate (β-TCP) (25%), resembling the inorganic phase of bone tissue extracellular matrix.

The Ossylbone™ as an alloplast material is bone substitute material obtained through laboratory chemical synthesis, what guarantee its full control over its chemical and physical properties. 

Bone substitutes represent as an a large group of biomaterials, designed especially to support the regeneration of bone defects or fractures in vast medical applications. Group of materials obtained with fully controlled chemical synthesis, so called alloplast, are most frequently based on hydroxyapatite (HAp) and tricalcium phosphate (β-TCP) and are proven to be significant option as a relevant tissue support during regeneration¹.

Biomimetic material Ossylbone™ is an alloplast, synthesized in laboratory under fully controlled conditions, in order to obtain a material that will maximally resemble the properties of the natural human bone. 

This allows to obtain Ossylbone™ bone substitute as a fully biocompatible, bioresorbable and osteoconductive material. Additionally, due to the way of synthesis, the Ossylbone™ material can be obtain in large quantities as well as in many different shapes and forms, providing ideal solution to majority of encountered clinical case².

Biomimetic Ossylbone™ material is structurally highly similar to the natural human bone tissue at the physical level. This is due to the fact that Ossylbone™ is characterized with the porosity at range of 50 to 90% with micro and micro pores staying within a range of <20µm - 500µm resembling on this the human bone structure and providing proper osteoconductivity³. The chemical composition of the Ossylbone™ material is based on two compounds: hydroxyapatite (HAp) and tricalcium phosphate (β TCP)- two of the main components of bone tissue ECM. Because of this Ossylbone™, also from a chemical point of view resembles human bone. Additionally the presence of naturally resorbable β TCP provides an additional source of osteoconductivity and source of calcium ions necessary for bone regeneration⁴. Among broad range of available Ossylbone™ options, there are forms of product that contain an additional compound- chitosan. Chitosan improves biomaterial to bone adhesion and has a bacteriostatic, and anti-inflammatory properties^5,6.

All of those properties introduce biomimetic Ossylbone™ material as a bone substitute with high biotolerance, biocompatibility, bioactivity, and osteoconductivity, that forms strong and permanent connection with surrounding bone tissue⁷.

Use of biomimetic Ossylbone™ bone substitute material has its rationale in vide range of different clinical situations where fast and reliable bone regeneration is required. This will include filling of different bones fractures, filling the space after the removal of the bone pathologies or bone cyst; filling the loss of bone after teeth removal of dental procedures where bone augmentation is needed⁸.

The product is meant to use by medical practitioners only.

Bone loss regeneration can be achieved with many different approach. There are number of clinical solutions proving better or not so satisfying results. Undoubtedly, use of an appropriate bone substitute is today the most popular approach with solid foundation based on many clinical eveidence¹. Considering the ideal graft for bone replacement, the autografts are considered as a golden standard option, both from a biological point of view, as well as from physical and chemical point of leading to the most predictable clinical outcome². 

However, the use of this graft type of the is strictly connected with second operation site, leading to an increase of infection risk, creation the defect and thus mechanical disturbance at the harvest site. Due to this, autografts have limited availability and use of them is related with relatively high-cost what together strictly limits their use. For the alternative treatment, the use of bone allograft (isolated from donor of the same species) or xenograft (isolated from different animals are considered as suitable alternative to autograft³. Yet, the use of those grafts is related with the increased risk of immune conflicts or transmission of the animal-derived diseases to the patient as well as with the high price⁴.

To overcome all the undesirable risks related with mentioned bone graft options, the use of alloplastic material has become more popular for the past recent years. This bone-like material is synthesized in fully controlled conditions in order to achieve a material that resemble the natural bone from physical and chemical perspective⁴. Thus, alloplast bone graft is inorganic, biocompatible, biotolerant, bioactive and osteoconductive bone graft substitute⁵. Additionally, alloplast bone grafts are biologically stable (they resorb slowly with no negative impact of bone cells) with volume maintenance, allowing cell infiltration and remodeling⁶. Additionally, alloplast bone graft material due to its origin is known as a fully biosafe with no possibility to transmit any diseases or pathogens to the patient.

Data show that composition of the alloplast bone substitute material which brings the most beneficial outcomes for the bone regeneration is based on hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP), which will mimics the inorganic part of the natural bone ECM. Biomimetic bone substitute materials with such compositions have been shown to be biocompatible and exhibit characteristics that enable new bone formation along their surfaces and within their pores⁷. The two phase composition ensures biostability by estimating the balance between the rate of material resorption and long term mechanical support of the regeneration site⁸. Some additional substances combined within the structure can provides a supplementary features. Occurrence of chitosan in product composition improves adhesion of bone substitute material to bone tissue, besides that it has a basteriostatic and anti-inflammatory properties^9,10. Eventually, the proper structure of the alloplast material and the appropriate size of the pores guarantees the osteoconductivity of the material and allow the bone tissue to overgrow the implant.

Taking into consideration that alloplast bone substitute material is created to mimic as much as possible the natural structure of the bone tissue, with established properties which ensures safety of this product and induces the osteoconductivity, this material is characterized as significant solution for bone regeneration.