Implai Professionals Products
FOR PROFESSIONAL USE ONLY.

The Lipotris™ liposomal composite gel, developed using the controlled manufacturing technology Lipotris Assembly Process (LAP™), is characterized by an organized composite structure with predictable and reproducible rheological properties, as well as increased resistance to hydrolytic degradation1.

As a result, Lipotris™—representing a new class of injectable products supporting joint function—provides a synergistic action of hyaluronic acid and liposomes, which additionally interact with lubricin, a surface protein of cartilage tissue. This unique synergy results in the articular surface being given an exceptionally low coefficient of friction2,3.

The resulting composite gel is capable of actively improving joint motion quality and enhancing the tribological properties of the joint environment. Consequently, therapy based on Lipotris™ offers accelerated pain reduction while maintaining a sustained clinical effect.

Lipotris™ composite gel is specifically designed for a regimen of three intra-articular injections into synovial joints affected by osteoarthritis (OA), with the aim of alleviating disease-related symptoms.

Each pre-filled syringe of Lipotris™ contains 44 mg of hyaluronic acid and 1.6 mg of synthetic liposomes in 2 mL of solution. The unique combination of high-quality hyaluronic acid and size-optimized liposomes forms a uniform composite gel characterized by superior lubrication potential within the synovial joint1.

In conclusion, Lipotris™ therapy effectively ameliorates key OA symptoms, such as pain and limited joint mobility, thereby significantly improving the quality of life of patients with osteoarthritis4.
  1. Data on file Biovico
  2. Forsey, R. W., Fisher, J., Thompson, J., Stone, M. H., Bell, C., & Ingham, E. (2006). The effect of hyaluronic acid and phospholipid based lubricants on friction within a human cartilage damage model. Biomaterials, 27(26), 4581-4590.
  3. Jahn, S., Seror, J., & Klein, J. Lubrication of articular cartilage. annual review of biomedical engineering. Wyd. University of Oxford–Bodleian Library on, 7(18), 16.
  4. Bakowski, P., & Madej, W. (2024). Liposomal intra-articular gel provides components for ultra-low friction in the synovial joint, thus improving clinical and functional outcomes of patients with osteoarthritis. Osteoarthritis and Cartilage, 32, S45-S46.
Supplementation of intra-articular injectable products is a clinically proven practice, known to improve the functional condition of OA-affected synovial joints, thus it is widely used as a medical therapy in orthopedics. Intra-articular injection of HA-based viscosupplement into OA-affected structure improves the synovial fluid viscoelasticity and passively enhances synovial fluid lubricating potential. Nevertheless, innovative products with improved composition are able to actively interact with joint tissues, reducing friction by changing the movement from sliding to rolling.

Lipotris™ is a liposomal composite gel formed with a 44 mg sodium hyaluronate and 1.6 mg liposomes provided in a the injection of 2 mL. The highly concentrated hyaluronic acid contained in Lipotris™ has precisely tailored physicochemical parameters, including an optimally high molecular weight. Additionally, Lipotris™ composite gel contains synthetic liposomes, created from phospholipids (1-palmitoyl-2-oleoyl-phosphatidylcholine, POPC) that have a strictly defined size.

The consolidated form of the composite structure of liposomes and hyaluronic acid is able to interact with lubricin, the surface protein of the cartilage, creating a surface with highly reduced friction, and thus improving the movement quality in the synovial joint1.

Lipotris™ therapy is perfectly safe due to the origin of its components. Hyaluronic acid contained in the product is manufactured in strictly controlled conditions in process of the bacterial fermentation using the Streptococcus sp. strain. Additionally, liposomes are formed from non-plant-derived phospholipids (POPC) in a strictly regulated process, so their properties are very well-defined. The combination of both is able to provide an exceptionally safe product that possesses no possibility for an induction of uncontrolled tissue response upon the intra-articular injection2.

Clinical data show that three consecutive injections of liposomal intra-articular composite gel Lipotris™ with 7 days intervals is clinically effective in ameliorating OA symptoms, starting already at 14 days after the first injection and present for at least 6 months3.
Package of Lipotris™ contains single pre-filled syringe of 2 mL.

The product is meant to be used by medical practitioners only.
  1. Petelska AD, Kazimierska-Drobny K, Janicka K, Majewski T, Urbaniak W. Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study. Coatings 2019;9(4):264. https://doi.org/10.3390/coatings9040264
  2. Altman RD, Bedi A, Karlsson J, Sancheti P, Schemitsch E. Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. Am J Sports Med. 2016;44(8):2158-2165. doi:10.1177/0363546515609599
  3. Bakowski, P., & Madej, W. (2024). Liposomal intra-articular gel provides components for ultra-low friction in the synovial joint, thus improving clinical and functional outcomes of patients with osteoarthritis. Osteoarthritis and Cartilage, 32, S45-S46.
Tribology of synovial joint
The synovial joint is a bearing-like structure created by four main elements: articular cartilage, subchondral bone, synovial membrane and synovial fluid, providing the expected, high performance motion in the musculoskeletal system. To ensure a correct motion quality, articular cartilage together with synovial fluid need to create an ideal tribological system, ensuring extremely reduced friction and wear protection at low and high loads. This is ensured by an appropriate interaction between articular cartilage and synovial fluid, in particular between cartilage surface proteins and synovial components, including hyaluronan, proteoglycans, various proteins such as albumin, globulin, fibrinogen and collagen, as well as phospholipids such as phosphatidylcholine2,3.
Enhancing tribology through exogenous supplementation
Development of joint pathological conditions like osteoarthritis leads to a decrease in the rheological properties of the synovial fluid and destabilization of tribological homeostasis of the synovial joint4. Thus, supplementation of injectable product which has ability to restore or even enhance the tribological homeostasis in the joint environment has strong scientific and clinical rationale.

Intra-articularly injected composite gel consisting of hyaluronic acid and liposomes can act as tribology architecture restoration factor and functions as an efficient solution for movement quality recovery. Additionally, the cartilage surface protein – lubricin – plays a crucial role in the mechanism of intra-synovial boundary friction reduction5. In details, interaction of liposomes and hyaluronic acid form a consolidated composite gel structure of Lipotris™, that upon the intra-articular injection interacts with lubricin on the articular cartilage surface6. Thus, Lipotris™ is able to create a complex, multilayer cover on the surfaces of the articular cartilage, transforming the relative motion from sliding to rolling and creating a surface with negligible friction
Tribosupplement mechanism of action
  • Lipotris™ is a composite of hyaluronic acid and liposomes that form a consolidated material6.

  • Upon intra-articular injection, Lipotris™ actively interacts with lubricin.

  • Mentioned interaction transforms the motion in the joint from sliding to rolling, providing a surface with negligible friction, providing the correct, high-quality joint movement

  • For this reason, Lipotris™ therapy is able to provide an exceptionally rapid and long-lasting clinical response.
  1. Greene GW, Banquy X, Lee DW, Lowrey DD, Yu J, Israelachvili JN. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci U S A. 2011;108(13):5255-9. doi: 10.1073/pnas.1101002108.
  2. Seidman AJ, Limaiem F. Synovial Fluid Analysis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing 2024.
  3. Jahn S, Seror J, Klein J. Lubrication of Articular Cartilage. Annual Review of Biomedical Engineering. 2016;18:235-258. https://doi.org/10.1146/annurev-bioeng-081514-123305
  4. Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C. Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update. Int J Mol Sci 2023;24(7):6405. doi: 10.3390/ijms24076405.
  5. Lin W, Mashiah R, Seror J, Kadar A, Dolkart O, Pritsch T, Goldberg R, Klein J. Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction. Acta Biomater. 2019;83:314-321. doi: 10.1016/j.actbio.2018.11.015.
  6. Petelska AD, Kazimierska-Drobny K, Janicka K, Majewski T, Urbaniak W. Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study. Coatings 2019;9(4):264. https://doi.org/10.3390/coatings9040264