Implai Professionals Products
Lipotris™ composite gel provides a synergistic action of hyaluronic acid and liposomes, which are able to further interact with cartilage surface protein – lubricin. This unique synergy creates a surface with exceptionally low friction2,3. As a result, Lipotris™ is identified as tribosupplement - a complete new class of joint supplement able to actively affect joint motion quality. As a result, therapy based on Lipotris™ tribosupplement provides an accelerated pain relief with a sustainable duration of clinical effect.

Lipotris™ composite gel, is a new-generation tribosupplement, tailored for three intra-articular injections into the synovial joints affected by osteoarthritis (OA) in order to alleviate the symptoms of the disease.

Lipotris™ contains 44 mg of hyaluronic acid and 1.6 mg of synthetic liposomes in 2 mL pre-filled syringe. A unique composition of high-quality hyaluronic acid and liposomes with dedicated size creates a uniform composite gel characterized by supreme lubrication potential in the synovial joint1.

Conclusively, treatment with three doses of Lipotris™ is able to ameliorate OA symptoms like pain and joint mobility limitation and thus significantly improve OA patients’ quality of life4.
  1. Data on file Biovico
  2. Forsey, R. W., Fisher, J., Thompson, J., Stone, M. H., Bell, C., & Ingham, E. (2006). The effect of hyaluronic acid and phospholipid based lubricants on friction within a human cartilage damage model. Biomaterials, 27(26), 4581-4590.
  3. Jahn, S., Seror, J., & Klein, J. Lubrication of articular cartilage. annual review of biomedical engineering. Wyd. University of Oxford–Bodleian Library on, 7(18), 16.
  4. Bakowski, P., & Madej, W. (2024). Liposomal intra-articular gel provides components for ultra-low friction in the synovial joint, thus improving clinical and functional outcomes of patients with osteoarthritis. Osteoarthritis and Cartilage, 32, S45-S46.
Supplementation of intra-articular injectable products is a clinically proven practice, known to improve the functional condition of OA-affected synovial joints, thus it is widely used as a medical therapy in orthopedics. Intra-articular injection of HA-based viscosupplement into OA-affected structure improves the synovial fluid viscoelasticity and passively enhances synovial fluid lubricating potential. Nevertheless, products with improved compositions are able to actively interact with joint tissues, transforming the relative motion from sliding to rolling, thusreducing friction and thus being determined as a new class of joint supplements- a tribosupplements.

Lipotris™ tribosupplement is a liposomal composite gel formed with a 44 mg sodium hyaluronate and 1.6 mg liposomes provided in a the injection of 2 mL. The highly concentrated hyaluronic acid contained in Lipotris™ has precisely tailored physicochemical parameters, including an optimally high molecular weight that stays in the range of 1400 to 2400 kDa. Additionally, Lipotris™ composite gel contains synthetic liposomes, created from phospholipids (1-palmitoyl-2-oleoyl-phosphatidylcholine, POPC) that have a strictly defined size.

The consolidated form of the composite structure of liposomes and hyaluronic acid is able to interact with lubricin, the surface protein of the cartilage, creating a surface with highly reduced friction, and thus improving the movement quality in the synovial joint1.

Lipotris™ therapy is perfectly safe due to the origin of its components. Hyaluronic acid contained in the product is manufactured in strictly controlled conditions in process of the bacterial fermentation using the Streptococcus sp. strain. Additionally, liposomes are formed from non-plant-derived phospholipids (POPC) in a strictly regulated process, so their properties are very well-defined. The combination of both is able to provide an exceptionally safe product that possesses no possibility for an induction of uncontrolled tissue response upon the intra-articular injection2.

Clinical data show that three consecutive injections of liposomal intra-articular composite gel Lipotris™ with 7 days intervals is clinically effective in ameliorating OA symptoms, starting already at 14 days after the first injection and present for at least 6 months3.
Package of Lipotris™ contains single pre-filled syringe of 2 mL.

The product is meant to be used by medical practitioners only.
  1. Petelska AD, Kazimierska-Drobny K, Janicka K, Majewski T, Urbaniak W. Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study. Coatings 2019;9(4):264. https://doi.org/10.3390/coatings9040264
  2. Altman RD, Bedi A, Karlsson J, Sancheti P, Schemitsch E. Product Differences in Intra-articular Hyaluronic Acids for Osteoarthritis of the Knee. Am J Sports Med. 2016;44(8):2158-2165. doi:10.1177/0363546515609599
  3. Bakowski, P., & Madej, W. (2024). Liposomal intra-articular gel provides components for ultra-low friction in the synovial joint, thus improving clinical and functional outcomes of patients with osteoarthritis. Osteoarthritis and Cartilage, 32, S45-S46.
Tribology of synovial joint
The synovial joint is a bearing-like structure created by four main elements: articular cartilage, subchondral bone, synovial membrane and synovial fluid, providing the expected, high performance motion in the musculoskeletal system. To ensure a correct motion quality, articular cartilage together with synovial fluid need to create an ideal tribological system, ensuring extremely reduced friction and wear protection at low and high loads. This is ensured by an appropriate interaction between articular cartilage and synovial fluid, in particular between cartilage surface proteins and synovial components, including hyaluronan, proteoglycans, various proteins such as albumin, globulin, fibrinogen and collagen, as well as phospholipids such as phosphatidylcholine2,3.
Enhancing tribology through exogenous supplementation
Development of joint pathological conditions like osteoarthritis leads to a decrease in the rheological properties of the synovial fluid and destabilization of tribological homeostasis of the synovial joint4. Thus, supplementation of injectable product which has ability to restore or even enhance the tribological homeostasis in the joint environment has strong scientific and clinical rationale.

Intra-articularly injected composite gel consisting of hyaluronic acid and liposomes can act as tribology architecture restoration factor and functions as an efficient solution for movement quality recovery. Additionally, the cartilage surface protein – lubricin – plays a crucial role in the mechanism of intra-synovial boundary friction reduction5. In details, interaction of liposomes and hyaluronic acid form a consolidated composite gel structure of Lipotris™ tribosupplement, that upon the intra-articular injection interacts with lubricin on the articular cartilage surface6. Thus, Lipotris™ is able to create a complex, multilayer cover on the surfaces of the articular cartilage, transforming the relative motion from sliding to rolling and creating a surface with negligible friction
Tribosupplement mechanism of action
  • Lipotris™ is a composite of hyaluronic acid and liposomes that form a consolidated material6

  • Upon intra-articular injection, Lipotris™ actively interacts with lubricin so it acts as tribosupplement

  • Mentioned interaction transforms the motion in the joint from sliding to rolling, providing a surface with negligible friction, providing the correct, high-quality joint movement

  • Because of that, Lipotris™ is a new class of intra-articular product, able to provide an exceptionally fast clinical response with appropriate persistence
  1. Greene GW, Banquy X, Lee DW, Lowrey DD, Yu J, Israelachvili JN. Adaptive mechanically controlled lubrication mechanism found in articular joints. Proc Natl Acad Sci U S A. 2011;108(13):5255-9. doi: 10.1073/pnas.1101002108.
  2. Seidman AJ, Limaiem F. Synovial Fluid Analysis. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing 2024.
  3. Jahn S, Seror J, Klein J. Lubrication of Articular Cartilage. Annual Review of Biomedical Engineering. 2016;18:235-258. https://doi.org/10.1146/annurev-bioeng-081514-123305
  4. Giorgino R, Albano D, Fusco S, Peretti GM, Mangiavini L, Messina C. Knee Osteoarthritis: Epidemiology, Pathogenesis, and Mesenchymal Stem Cells: What Else Is New? An Update. Int J Mol Sci 2023;24(7):6405. doi: 10.3390/ijms24076405.
  5. Lin W, Mashiah R, Seror J, Kadar A, Dolkart O, Pritsch T, Goldberg R, Klein J. Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction. Acta Biomater. 2019;83:314-321. doi: 10.1016/j.actbio.2018.11.015.
  6. Petelska AD, Kazimierska-Drobny K, Janicka K, Majewski T, Urbaniak W. Understanding the Unique Role of Phospholipids in the Lubrication of Natural Joints: An Interfacial Tension Study. Coatings 2019;9(4):264. https://doi.org/10.3390/coatings9040264